), I would also add the inverted cards, The Stars? Cube of Meat after defeating a Horseman, REPENTANCE - It is now possible to see items again that have been rerolled away, preventing emptying the item pool and 'Breakfasting', REPENTANCE - Chaos now assigns a "weight" to item pools based on how many items are in the pool. He won't respawn even if you move to a new floor, Will always match your current movement speed, UNLOCK: Unlock this item by defeating The Beast as Tainted Keeper, Only found in the Mausoleum/Gehenna II boss room, The item itself has no effect, but triggers the ascent through the backwards path towards the Home floor. blue, glow, 69, Isaac increases in size, gets a lion's mane and now has the ability to crush rocks by walking over them, Crushed rocks and poop can fill holes if you walk in their direction, Allows you to crush Red Poops and sometimes not take damage. the Secret Room or the Shop, Every time the portal sucks up an item, it spawns a blue attack fly for you, Once every room has been explored, the portal does nothing, Cannot take you to rooms that aren't a part of the floor structure e.g. This effect is stackable, *, the lost item pool, pink, red, guts, intestine, tube, Gives Isaac a higher chance to find hearts from drops after clearing a room and from chests, * , the lost item pool, red, purple, childs heart, child heart, UNLOCK: Unlock this item by beating the Dark Room with Judas, Gives Isaac a higher chance to find keys and chests, Grants a secondary chance of any non-specific heart drop turning into a soul heart, * , the lost item pool, white, grey, gray, circle, round, moms pearl, The fire rate increase is applied in such a way that the higher your tear stat is, the more effective Cancer is, Breaks the normal fire rate cap, allowing you to fire faster than the normal maximum, You have a chance when taking damage to gain +1.8 Damage Up for the rest of the room, Gives Isaac a higher chance to find bombs, Picking up the Match Stick is the only way to remove the Tick trinket, UNLOCK: Unlock this item by blowing up 20 shop keepers (this includes the ones in the secret room), When you take damage while on 1/2 a heart, you are teleported back to the previous room. Great list! and IBS also have special effects: Stone Dips deal 3.5 more damage and can take 6 hits before they die. REPENTANCE - White poop from Hallowed Ground is now more durable, similar to golden poop. If you've played Antibirth before or watched people play it, Repentance is basically that but official. grey, gray, feet bobby bomb, When used, deals damage to Isaac in exchange for +1.2 damage up which lasts for the current room, The first use per room takes 1 full heart, then 0.5 hearts per use after that. This will deviate you from the alt path if you are currently on it, Since this item resets your stats, this item can remove Broken Hearts, UNLOCK: Unlock this item by defeating Greedier Mode as Jacob & Esau, Item Pool: Angel Room, Greed Mode Angel Room, Upon use, allows you to consume 1 key and fire it at an enemy, piercing enemies and dealing significant damage, The damage done by the key projectile pierces through enemies and scales with your damage upgrades (x5 damage + 30), Keys fired by this item can open locked doors/chests, secret rooms and destroy objects in the room, such as rocks, Cannot be used if you don't have any keys, Enemies killed by Sharp Key have a ~10% chance to spawn random items that appear in a chests. 5 keys = 100% chance. The Binding of Isaac Repentance: How to Get Mega Mush You should know that you can choose to make the item or keep sliding items and picking them up, and placing them in the bag, which will remove the first item obtained and roll the others forward. The beams of light now trail behind Isaac when charging with it (damage formula of the beams is damage * 4 + 10). Each tick of poison damage is equal to your normal tear damage, Some random tears will gain the Rubber Cement effect and become bouncy, Grants +0.25 Speed, +0.75 Range, +0.1 Shot Speed, +0.2 Tears, +0.5 Damage and +1 Luck when Isaac's active item is fully charged, Infinite use items such as Potato Peeler count as charged and provide the bonus from this trinket, Grants +0.5 Speed, +1.5 Range, +0.3 Shot Speed, +0.4 Tears, +1.5 Damage when Isaac's active item is completely uncharged, One-time use items such as Mama Mega count as uncharged and provide the bonus from this trinket, Gives you another secret room on each new floor while held, Does not spawn more than one super secret room, only the normal secret room, *, purple, torn, ripped, paper, page, poster, When you have the same amount of coins, bombs and keys, half consumables turn into their doubled version, This effect works for any number of consumables, including 0 and 99, as long as the count for coins/keys/bombs is equal, Every time you take damage you have a very small chance to spawn a random pedestal item, When the effect triggers, the trinket is destroyed, Every time you take damage you have a very small chance to spawn the Lunch item, which gives +1 HP up, When the effect triggers, this trinket is destroyed, Increases the radius of any creep you produce, While held, any damage taken remove red hearts first, before soul hearts, black hearts and rotten heart damage, While at 1/2 of a red heart, it will begin to remove your other hearts again, UNLOCK: Unlock this item by beating Greedier mode with Eve, The Walnut has a chance to break when taking damage from an explosion. Red chests), Can be used in a shop to duplicate pickups which have not yet been purchased, and take the duplicate pickup for free, UNLOCK: Unlock this item by defeating Greedier Mode with Isaac, When used, Void will consume any pedestal items in the current room, If an active item is consumed, its effect will be added to Void's effect when used, allowing you to consume multiple items and combine their effects, If a passive item is consumed, you gain a small stat upgrade to a random stat, Possible stat changes include: +1.0 flat damage, +0.5 tears, +0.2 speed, +0.2 shot speed, +0.5 range, +1.0 luck, Void does not work on devil deal or shop items unless they have been bought first, Using Void to absorb items in Boss Rush or Challenge Rooms counts as taking the items and will cause the encounter to start, Using Void on one time use items such as Mama Mega or Diplopia will cause their effect to instantly trigger and will not give you further uses through activating Void again, UNLOCK: Unlock this item by beating Delirium in The Void floor with Apollyon, Upon use, this item freezes all enemies in the room until you press the fire button again or 30 seconds passes (whichever happens first), Unlike other active items, bosses are not immune to this effect, Touching a frozen enemy will still hurt you, This item doesn not affect troll bombs - they will still explode, Upon use, the Smelter will destroy your currently held trinket and give you the effect permanently, allowing you to stack up lots of different trinket effects, Holding the Smelter increases the chance for a trinket to drop. Using active items gives a damage up that scales with the charge time, ??? This is the strongest Shop item in the entire game. Defeating Mega Satan as one of the B-side characters unlocks a whole new object a la Lucky Pennies. He behaves the same as how Esau works with Jacob, following your exact movements, Disappears after the current room or if he takes enough damage and dies, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Forgotten, Creates 6 wisps, similar to the Book of Virtues effect, Mosts wisps will be the standard blue ones, but have a chance to have random special properties, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Bethany, Spawns Esau as a temporary familiar, who copies your exact movements the same as how the Jacob & Esau character works, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Jacob, Once picked up, you gain unlimited key use for the rest of the floor, Using a 'Bombs are Key' pill with this effect will swap your Gold Key for a Gold Bomb, Once picked up, you gain unlimited bomb use for the rest of the floor, Using a 'Bombs are Key' pill with this effect will swap your Gold Bomb for a Gold Key, UNLOCK: Unlock this item by beating challenge #23 (Blue Bomber), Fully charges your active item when picked up, Also, you take a full heart of damage when picked up. Repentance introduces a whole new mechanic of Red Rooms - extra rooms attached to the current floor. Upon use, this item summons a ghost near Isaac that will follow him around. (Does not roll your devil deal items), 5 Dot - Reroll and restart the current floor (Forget Me Now effect), 6 Dot - Reroll all of your items and all the pickups on the entire floor (Combined 1 + 3 + 4 rooms), The same order as the in-game collection page. If used with Brimstone you have a 100% chance to fire a laser out the back of your head, * dungeon room, blood challenge room, arena pool, item room, treasure room, item room pool, Boosts speed, range, shot speed, tears and damage if they are above their base values by roughly +20%, Affects stat bonuses from passive items, trinkets that are absorbed or in a second trinket slot, and permanent bonuses given by items such as Void, UNLOCK: Unlock this trinket by getting a 5-win streak in daily challenges (must have a score of above 0 on the score screen), While held, gives the Skatole effect only in certain rooms, which will turn hostile flies to neutral and stop others from shooting, Attack, Dart and Ring Flies turn into neutral Black Flies and Pooters and Fat Flies will no longer fire at you, Items and trinkets which generate blue flies and spiders will have double the effect, causing twice as many to spawn, *, grey, gray, green, arrow, flower, plant, Some tears will randomly become a black tooth, that deal double your normal tear damage and can poison enemies, Tears become spectral and travel in a huge spiral pattern, Every time you take damage you have a very small chance to gain a Tonsil familiar, which follows you and blocks enemy projectiles, This effect can happen twice before the Tonsil trinket is destroyed, Your tears have a random chance to become booger tears, Booger tears stick on to enemies and deal periodic poison damage until they die or 60 seconds passes. Any item that unlocks Red Rooms is also a good one to prioritize for this reason, such as Soul of Cain (Boss Rush and Hush as Tainted Cain), Crystal Key (Mother as Tainted Lost), and Reverse Moon (Greedier as Tainted Jacob). This mechanic is absolutely nuts - not only can you get multiple extra rooms of room clear rewards, but Red Rooms are used to access the Ultra Secret Room, where you can get free Angel Room items. Any other enemies hit by these shards will become frozen too, Frozen enemies are considered dead by the game, and won't unfreeze or move again. Holding this trinket increase that chance by +15%. box, yellow, grey, When used, converts 1 soul/black heart into 1 red heart container, This item will take from your soul hearts first, REPENTANCE - Converter now only costs one soul heart to use (previously costed two), * shop room pool, shop item pool, the lost item pool, blue, gray, grey, yellow, sprocket, When used, this item will spawn a set of items or consumables based on which chapter you are currently on, Basement 1: 2 Soul hearts. Once you have this key, you can then unlock the two characters. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. Enemies include Candler, Lil' Haunt, Polty, Red Ghost, Wizoob and The Forsaken, The Haunt, The Heretic and The Rainmaker bosses. hearts, keys, bombs, coins, pills, cards, trinkets, batteries etc, After the first drop, he has a 67% chance to drop a pickup after 3 coins and a 33% chance to drop a pickup after 4 coins, Bum friend also has a chance to spawn items from the Beggar Item Pool, Counts as 1 of 3 bum items needed towards the Super Bum transformation, * item room, treasure room, item room pool, baby, pink, Item Pool: Devil Room, Curse Room, Red Chest, Gold/Stone Chest, * curse room pool, red chest pool, red chest item pool, golden chest pool, gold chest pool, devil pool, devil room pool, devil deal, dead, cat, grey, gray, guppy head, guppys head, Taking an eternal heart to the next floor or collecting two on the same floor gives you an extra heart container, * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, Kicking a frozen enemy will push it into the wall, where it shatters and fires ice shards everywhere (these can then freeze other enemies), Enemies touching the cube while it's not moving or moving slowly will become slowed for a few seconds, and take a small amount of damage, Cube Baby and enemies frozen will block enemy shots, Cube Baby can be launched across the room if you have a melee weapon, Enemies that die now spawn a red ghost, that floats in place of where the enemy died, Activating the item causes all red ghosts in the room to explode, dealing damage to any enemies near them, The explosion doesn't deal damage to Isaac, Damage dealt by each ghost is 3 + 0.04x the HP of the enemy it spawned from, Larger enemies such as minibosses will spawn a larger red ghost that causes 3 explosions, The red ghosts can be moved around slightly by firing tears through them, Using the item will instantly kill any enemy or boss that has the 'ghost' tag and is at 50% or less HP. UNLOCK: Unlock this item by beating the Isaac boss with Azazel, * the satanic bible library pool, library room, book room pool, devil pool, devil room pool, devil deal, item room, treasure room, item room pool, the lost item pool, pentagram, star, grey, gray, red, When used, fires a 4 way brimstone laser in all cardinal directions, dealing a lot of damage to any enemies, Laser damage does not scale with your damage stat - its a fixed 10 damage per tick for 20 ticks (200 total per use), Has a chance to drop after you beat Krampus, If you get close enough to an enemy that has a large hitbox, you can hit it with 2 of the laser beams, allowing you to deal more damage, UNLOCK: Unlock this item by beating Krampus (Krampus is unlocked by taking 20 devil deal items), *, horns, grey, gray, white, red, dead, tongue, krampus head, When used, farts on nearby enemies and knocks them backwards away from Isaac, Allows you to reflect projectiles away from Isaac, REPENTANCE - Butter Bean now knocks back enemies and projectiles with significantly more force. 'One Makes you Larger' pills, Magic Mushroom etc, *, mtg, card, magic, gathering, green, brown, giant growth, Spawns 3 random cards on the floor when used, When used, this card will slow down enemies, Isaac's tears by -1 Shot Speed, but speed up Isaac's movement speed by +0.50 for the rest of the current room, UNLOCK: Unlock this item by getting both the Broken Watch and the Stop Watch in your collection, When used, removes the price tag from all items in the current shop or devil deal, making everything free, The effect of the Credit Card only lasts for the current room, UNLOCK: Unlock this card by beating Challenge #10 (Cursed!). UNLOCK: Unlock this item by defeating Isaac as Jacob & Esau. Doing so will cause it to increase in size, and also increase their damage and the damage of the burst tears, Once a tear is fed 5 times, it will immediately burst, Tears in the burst will deal half the damage the main tear would have, Added as part of the Afterbirth+ Booster Pack #4. From the Sacred Heart to the Magic Mushroom and the mighty Brimstone, here are some of the best and strongest items available in The Binding Of Isaac. This doesn't work with The Lost characters, While in a room with enemies, red cracks will appear on the floor in random locations, Walking over the crack spawns a white soul familiar, that launches itself into the nearest enemy, exploding and dealing double your tear damage to everything near it, Cracks will keep appearing but only one can exist in the room at a time, UNLOCK: Unlock this item by defeating challenge #38 (Baptism by Fire), While held, this item spawns a familiar that can be moved around using the arrow keys and deals 1.5 damage per tick to any enemies it touches, When activated, you teleport, swapping places with wherever Stitches was positioned, Teleporting next to fires will extinguish them (including blue fires) and on top of shopkeepers will destroy them (gives +10% devil/angel room chance as normal), If used while stitches is on top of an enemy, it can be used to telefrag enemies, dealing x3.5 your damage + 40, Can be used to enter/exit Curse Rooms for free by teleporting infront of the door while holding the direction key to move in immediately. Cannot be rerolled by 4-pip dice rooms and Spindown Dice, Clearing a room will spawn an extra reward, however only one can be picked up - the other one will disappear, UNLOCK: Unlock this item by defeating the The Beast as Isaac, Every half red heart you pick up gives a small but permanent stat increase, Randomly picks between +0.10 Damage Up, +0.05 Tears Up, +0.15 Range Up, +0.02 Speed Up, +0.1 Luck Up, +0.02 Shot Speed Up per half red heart, UNLOCK: Unlock this item by defeating The Beast as Magdalene, This item causes Devil deals to cost money instead of hearts, and shop items to cost hearts instead of money, Shop items cost heart containers, and pickups have spikes around them, The Devil deal conversion rate is 1 heart container to 15 coins, Devil deal items can be on discount similar to the shop, making it 1 heart container = 7 coins instead, UNLOCK: Unlock this item by defeating The Beast as Cain, Every time you enter a devil room and choose not to take an item, you get +1 Damage Up upon entering the next floor, The effect is shown via a cross above Isaac's head. Every so often it will come up and attempt to grab onto a random enemy in the room, holding them in place and dealing damage, The Worm Friend deals 4 damage for 8 ticks total, If the enemy moves quickly enough it can miss its attack, UNLOCK: Unlock this item by defeating The Beast as Apollyon, Enemies that die will leave behind 1-2 floating bone shards where they die, until you leave the room, Other enemies that touch the bone shards will take 3.5 damage, with a chance to either bounce off them or cause it to break and disappear, UNLOCK: Unlock this item by defeating Mother as The Forgotten, Each time an enemy dies, a friendly red soul appears. They also no longer block player attacks or get extinguished by them, UNLOCK: Unlock this item by donating 400 pennies to the Shop, Isaac can now pick up hearts while at full health, which will be stored in the Jar and can be spawned again using the spacebar, Soul hearts and black hearts cannot be stored, If used in a Black heart or Eternal heart super secret room, it will spawn the relevant heart, * shop room pool, shop item pool, the lost item pool, glass. - When used, shoots an Ipecac explosive shot. Releasing Dark Esau will cause him to charge directly at Jacob and deal damage to anything in his path. If picked up by Cain, it shoots blood tears and the damage becomes increased to 5 (instead of the usual 3.5), UNLOCK: Unlock this item by beating the Dark Room with Cain, * golden chest pool, gold chest pool, item room, treasure room, item room pool, follower, everyone knows it's abel, brown, grey, gray, dead, head, grey, green cain and abel cain & abel, UNLOCK: Unlock this item by beating Challenge #14 (It's in the Cards), * item room, treasure room, item room pool, bloody, silver, grey, gray, sharp, Item Pool: Item Room, Secret Room, Bomb Beggar, * secret room pool, item room, treasure room, item room pool, smile, face, grinning, doitfgt, REPENTANCE - The list of possible tear effects was updated in Repentance, to include all missing and new ones, * item room, treasure room, item room pool, pink note, money, cash, three dollar bill, Unlocked from the 'Once more with the feeling!' - Spawns one blue attack spider for every enemy in the room. On Bethany and J+E, i didn't encountered this glitch. The locust fly will do different things for each harbinger - e.g. After taking two hits, the fire will be extinguished, The Book can be held at the same time as another active item. Essentially you are rerolling all your items, but each new item you get to choose between 3 random options, The bedroom also contains a random trinket, 2 chests, 2 sacks and Isaac's bed, which can be used to full heal your red heart health, The only way to exit Isaac's bedroom is teleporting out or via the trapdoor, which takes you to the next floor. This is intended give you a guaranteed way to teleport out of the Mom's Foot fight, for accessing the path to the Mausoleum floor. Based loosely on the Steam Workshop mod created by Extreme Ninja Home Makeover with changes by Edmund McMillen, *, lepracy, leprasy, leprosy, pink, red, bloody, lump, Gives you a random Harbinger familiar that changes every 10 seconds, Each harbinger behaves differently, based on any of the original 5 horsemen bosses, REPENTANCE - The harbingers will also randomly spawn their relevant Locust variant. Based on the Steam Workshop mod created by Merlo. a bomb can become a troll bomb, or a dropped coin can become a dime, UNLOCK: Unlock this trinket by defeating Isaac, ?? poop, When used, you have a 50% chance to double all items, consumables and chests in the current room, If the effect fails, all pickups and items are deleted and Crooked Penny spawns 1 coin, If there are no consumables currently on the floor, Crooked Penny spawns 1 coin, This item works with items which can be purchased such as shop items, allowing you to spawn a free version if the effect triggers, If used in a shop and the effect fails, a Restock box can be used to restore the shop items. Upon hitting the last button, this unlocks a Mine Cart, which is somewhere on the floor. Supper = +0.5 tears, +1 luck. Function: Gives access to the Blue Womb no matter the time elapsed, Special interaction with Pandora's Box (consumes both for 6 random items), Unlock Condition: Defeat Isaac, ?? The damage done by Glass Cannon is calculated as follows: dmg = (dmg * 10) + 10 (i.e. ?, Satan and The Lamb as Tainted Apollyon, Gives you a red attack fly, that will charge at enemies in the same direction you are shooting, Deals damage equal to your current tear damage, Stops charging once it hits an enemy and returns to Isaac's side, UNLOCK: Unlock this trinket by defeating Mother as Tainted Apollyon, Gives a 33% chance to spawn an extra blind pedestal item in all future item rooms. When the charge bar gets to zero it will grant you a brief period of invincibility, If the spacebar is held for too long (about 1 second) when it has no charge, you will take damage, During the invincibility period, Isaac deals 3.5 contact damage to enemies and beams of light will strike down from the sky, dealing 15 damage, If damage is blocked perfectly at the exact second the charge bar reaches zero, it will release holy beams in four directions and grant a brief shile effect, The invincibility effect is shown via a rapid flashing animation, * angel room pool, god room pool, angel room item, white, blue, ball, circle, After taking damage, if you have half a red heart or less, The Polaroid will give you an invincibility shield for 5 seconds, Allows you to open the door at the beginning of Depths II that leads to the Mausoluem, When unlocked, is guaranteed to drop after the Mom's Foot boss fight, The Polaroid will always spawn on the left pedestal, UNLOCK: Unlock this item by beating Isaac in the Cathedral 5 times, After taking damage, if you have half a red heart or less, The Negative will deal 40 damage to all enemies in the room, The Negative will always spawn on the right pedestal, UNLOCK: Unlock this item by beating Satan in Sheol 5 times, * mom's foot, mom fight, mom boss, dark room, photo, family, kodak, inverted, You no longer shoot tears and instead now control a single large tear with the arrow keys, Items which increase your tears stat will cause the tear to deal damage at a faster rate, Items which increase your shot speed cause the tear to travel faster across the screen, Ludo and Brimstone create a large controllable red ring of death that does massive damage to anything in its path, Taking this with Mom's Knife allows you to remote control the knife around the room, dealing huge damage, * item room, treasure room, item room pool, eye, pink, grey, gray, robot, REPENTANCE - Soy Milk tears now cause drastically less knockback, * item room, treasure room, item room pool, white, glass, square, Isaac's tears become homing and have an aura around them, which will deal a flat 2 damage per tick to anything inside its radius, Multiple GodHeads doesn't stack the aura damage, UNLOCK: Unlock this item by completing all post-it note marks in hard mode with The Lost character, * angel room pool, god room pool, angel room item, yellow, blue, red, triangle, all seeing eye, Gives Isaac an extra life on death, exactly the same as Lazarus' default respawn effect, When you die with this item, you respawn in the same room with 1 heart and the Anemic item, The game considers you to be a different character (Lazarus II) when this effect activates, UNLOCK: Unlock this item by beating the Isaac boss with Lazarus, * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, In his path is basically that but official Satan as one of the B-side characters unlocks Mine! 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